What’s New With PSS

April Newsletter

 April Newsletter The April 2015 PSS AccuSizer and Nicomp news included the following topics:  Invitation to Nicomp DLS webinar New technical document: Why Buy a Nicomp New application note on liposomes New web page: Introduction to the AccuSizer New article on protein aggregation Read the complete newsletter

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March 2015 Newsletter

March Newsletter The March 2015 PSS AccuSizer and Nicomp news included the following topics:  Invitation to SPOS webinar New technical support documents; Nicomp system verification and AccuSizer count standards procedures New application note on CMP filter efficiency New web pages: Online DLS systems and 2015 trade shows Read the complete newsletter.    

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Document Download Center

Visit the new Document Download Center to automatically download documents including:     Brochures Application Note Technical Notes Just fill in your name, company, location, and email address and you can then download any of the available material.

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October Newsletter

October Newsletter Highlight: Using Online DLS to Monitor Production of Nanoparticles for Drug Delivery Online Monitoring of Nanoparticles for Drug Delivery         Research into nanoparticles for drug delivery is now turning into products on the market. The particle size distribution is a critical physical property that influences quality and yield. Most companies…

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Protein Aggregation

Aggregation in protein solution based therapeutics can have deleterious effects such as inducing a response from the immune system.  Measurement of these aggregates has been possible for larger aggregates, but smaller aggregates in the range of 0.150 nm to 2 microns have been difficult to quantify.  Dynamic Light Scattering (DLS) techniques can demonstrate the existence…

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Zeta Potential BSA

Unlike the small organic molecules that have traditionally been used in drugs, proteins have chemical and physical properties that can cause instability and product variability. Instability occurs when protein therapeutics undergo chemical and physical changes during manufacturing, shipping, storage and administration. Physical instability such as aggregation or precipitation can negatively affect drug dosage, efficacy, and…

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Isoelectric Point of Protein

With the Nicomp 380 ZLS it is possible to not only size proteins but also determine their isoelectric point (IEP). Ampules of bovine serum albumin (BSA) were purchased from Sigma Aldrich and diluted 1:100 with deionized water. Figure A below shows the volume-weighted mean particle diameter to be 5.5 nm. Aggregates of ~25nm were also detected.…

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PSS to discuss protein aggregation

The technique of single particle optical sizing (SPOS) is known to produce particle size distribution (PSD) results of highest sensitivity and resolution over a wide size range, making it a uniquely powerful tool for assessing the quality and stability of a wide range of colloidal dispersions and suspensions. In particular, SPOS based on the method…

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The Nicomp 380 Splits another Bimodal

The Nicomp 380 was out in the field recently for a demonstration with a major chemical company and the operator was presented with a customer-made bimodal prepared by mixing a 150 nm polystyrene latex and a 350 nm polystyrene latex together to form a bimodal particle size distribution. And once again, without any input from…

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