Nanoparticle Size Analysis

The typical definition of a nanoparticle is a particle with a size between 1- 100 nm. The term has been defined this way in both ISO standard 27687 and ASTM standard 2456-06. In the EU the definition is more clouded because of the wording used concerning that about 50% of the number distribution should be between 1-100 nm.

Dynamic light scattering (DLS) remains the most popular particle size analysis technique for nanoparticles. The Nicomp DLS system is used in many industries to measure the size of nanoparticles, both in the lab and online in the process environment.

Read the sections below for more information on using the Nicomp DLS systems to measure the particle size of nanoparticles.


Read the sections below to learn more about these protein applications.

Extremely small particles can be sized with DLS.

Dynamic Light Scattering (DLS) is a standard time tested method for sizing dispersions of nanoparticles. It is the only optical particle sizing technique that can reliably size particles below 10 nanometers.   Figure A illustrates this capability. The PSD in this figure is from a commercial Buckminster Fullerence (C60) or Bucky-Ball suspension. C60 has a…

Broad distributions can be sized with DLS

Dynamic Light Scattering if often disparaged for not being able to handle broad distributions. This is not the case.   It is true that the deconvolution algorithms used to convert correlation functions into particle size distributions will produce a stylized graph. For example, in Figure A, the PSD of a re-constituted nano-powder is shown. The…

Online Size Analysis of Nanoparticles

Nanomedicine research has grown quickly during the past few decades with much of the focus placed on drug delivery. Nanoparticles provide benefits such as reducing toxicity and side effects. Controlling the size of these nanoparticles is critical. While the majority of the particle size measurements of this product is in the lab, it is now…