Droplet size and zeta potential are critical indicators of emulsion stability
Emulsions are two phase dispersion of liquids that are normally not miscible. The most common examples are oil in water and water in oil emulsions. The particle size and zeta potential of the emulsion droplets are important physical characteristics that influence emulsion stability. The droplet size can be measured on either the Nicomp DLS system or the AccuSizer SPOS system. The Nicomp can also measure the zeta potential during the formulation in order to optimize the surface chemistry to optimize dispersion stability.
AccuSizer for measuring emulsions
Specific applications where the AccuSizer is extensively used to measure emulsions droplet size includes lipid injectable emulsions (total parenteral nutrition, or TPN) following the USP <729> Method II testing procedure and soft drink flavor emulsions.
The Nicomp is often used for USP <729> Method I testing and microemulsions.
Read the sections below for additional information on these applications.