Applications

PSS-Emulsion

Emulsions

Droplet size and zeta potential are critical indicators of emulsion stability Emulsions are two phase dispersion of liquids that are normally not miscible. The most common examples are oil in water and water in oil emulsions. The particle size and zeta potential of the emulsion droplets are important physical characteristics that influence emulsion stability. The…

Proteins

Measure Protein Size and Aggregation The Nicomp DLS and the AccuSizer SPOS systems are frequently used to measure the size, aggregation, and surface charge (zeta potential) of proteins. The Nicomp DLS system has the sensitivity to measure monomers, dimers, and trimers at small sizes and at low concentration – including lysozyme at 01. mg/mL. AccuSizer…

Chemical Mechanical Polishing

Chemical Mechanical Polishing Click image to watch presentation The PSS AccuSizer is recognized as the most accurate and sensitive system for detecting large particle counts (LPC) in CMP slurries. While laser diffraction can measure the mean size of the distribution well, the single particle optical sizing (SPOS) technique in the AccuSizer is hundreds of times…
PSS -Particles in Oil

Contamination

Resolution, Sensitivity & Autodilution for Contamination Applications The AccuSizer is a sophisticated liquid particle counter used for various particulate contamination applications. Low concentration samples can be analyzed using either the AccuSizer A2000 or SIS systems. The AccuSizer A2000 can also be configured to automatically dilute concentrated samples such as motor oils. Common AccuSizer contamination applications…

Inks & Paints

The AccuSizer detects the oversize particles in inks & paint The particle size of pigments used in inks & paints is an important physical characteristic that affects both appearance and functionality. This is particularly true for inks used in inkjet cartridges where large particles could plug the jets and channels. Popular technique for inks &…

Nanoparticles

Nanoparticle Size Analysis The typical definition of a nanoparticle is a particle with a size between 1- 100 nm. The term has been defined this way in both ISO standard 27687 and ASTM standard 2456-06. In the EU the definition is more clouded because of the wording used concerning that about 50% of the number…

Microbubbles

Particle Size and Count of Microbubbles The AccuSizer is the most common instrument used to measure the size and concentration of microbubbles used in a variety of applications including contrast agents and targeted drug delivery. Microbubbles can also be used to treat thrombosis and vascular plaques. The particle size of the microbubbles is a critical…
PSS-Parenterals

Parenterals

Subvisible Particles Detection in Parenteral Drugs Parenteral drugs are delivered into the body by directly injecting into the intravenous, subcutaneous, or intramuscular routes. Subvisible particle counting in parenteral drugs is described in USP <788>, a common application for the AccuSizer SIS system. The same system can also be used for USP <789> for ophthalmic solutions…
PSS Isoeletric Point

Isoelectric Point (IEP)

Isoelectric Point The isoelectric point (IEP) of a dispersion is the pH value where the zeta potential equals zero. This is the condition that is least stable and frequently leads to agglomeration for suspensions and phase separation for emulsions. Determining the IEP is a common zeta potential application for the Nicomp DLS particle size and…
PSS-Filter

Filter Testing

Filter testing efficiency The AccuSizer liquid particle counter is used to test a wide range of filters. This may involve using two sensors upstream and downstream of the filter in order to calculate the efficiency at given size ranges. A common calculation used for filter testing is the beta ratio: Optimum filter replacement conditions Other…

Liposomes

Size and Zeta Potential of Liposomes A liposome is a spherical vesicle having at least one lipid bilayer used for drug delivery. Most liposomes are measured using a DLS system like the Nicomp. But larger liposomes have been successfully analyzed using the AccuSizer SPOS system. Read the section below to find out more about this application.